Measurement of blood clearance time byLimulusG test ofCandida-water soluble polysaccharide fraction, CAWS, in mice

Noninvasive real-time measurement of nasal mucociliary clearance in mice by pinhole gamma scintigraphy.

Mucociliary clearance (MCC) is the key defense mechanism in the upper airways, as the removal of debris-laden mucus in the sinuses completely depends on MCC. So far, how the nasal MCC is regulated remains unknown. Recently, mice deficient in genes encoding the components of MCC apparatus have been generated, which will allow investigators to conduct more in-depth nasal MCC studies. However, the...

Murine model of Kawasaki disease induced by mannoprotein-beta-glucan complex, CAWS, obtained from Candida albicans.

Intraperitoneal administration of CAWS (water-soluble extracellular polysaccharide fraction obtained from the culture supernatant of Candida albicans) to mice induces coronary arteritis similar to Kawasaki disease. We analyzed differences in the production of cytokines involved in the occurrence of coronary arteritis among mouse strains, C3H/HeN, C57BL/6, DBA/2 and CBA/J. The incidence of arter...

Histopathological effects of water soluble?fraction of crude oil on liver tissue of fingerling beluga , Huso huso Linnaeus, 1754

In this study the LC50 96h values of water-soluble fractions (WSF) of the Caspian Sea ? exploited crude oil were determined in beluga, Huso huso fingerlings. The fingerlings averaged 2.42 ? 0.11 g in weight were exposed to WSF crude oil at concentrations 24.75, 27, 29.25, 31.5, 33.75, 36, 38.25 ppm. The treatments were performed in three replicates and all changes in the specimens were determin...

Development of Capacitance Void Fraction Measurement Method for BWR Test

Effect of CAWS, a mannoprotein-beta-glucan complex of Candida albicans, on leukocyte, endothelial cell, and platelet functions in vitro.

Candida albicans is a medically important fungus which induces a disseminated candidasis and candidemia in immunocompromised hosts, and releases a polysaccharide fraction into the blood. We recently found that C. albicans released a water-soluble polysaccharide fraction (CAWS) into synthetic medium and demonstrated that CAWS was mainly composed of a complex of mannan and beta-glucan. In the mur...